Oflox 400 Mg (Ofloxacin)

Description

Introduction

Oflox 400 Mg is an oral prescription antibiotic formulation designed to treat a variety of susceptible bacterial infections. Containing ofloxacin as its active therapeutic agent, this medication belongs to the synthetic fluoroquinolone class of antimicrobials. Fluoroquinolones are utilized in clinical medicine for their broad spectrum of activity against both Gram-negative and select Gram-positive bacterial pathogens responsible for respiratory, urinary, and soft tissue conditions.

This product description provides catalog information regarding the functional profile, pharmacological actions, safety considerations, and regulatory precautions associated with Oflox 400 Mg. Proper treatment requires professional medical consultation and a valid prescription from a registered medical practitioner to ensure appropriate diagnosis, regimen selection, and patient safety.

What Is It?

Oflox 400 Mg is a pharmaceutical preparation delivered in an oral tablet form. Each film-coated tablet contains 400 mg of the active pharmaceutical ingredient ofloxacin. It is formulated to deliver a precise systemic dose for managing moderate to severe bacterial infections under healthcare supervision.

As a broad-spectrum antimicrobial agent, ofloxacin targets bacterial organisms specifically without exerting direct antibacterial action against viral infections such as influenza or the common cold. It is classified as a synthetic antimicrobial agent within the fluoroquinolone drug class.

How Does It Work?

Ofloxacin exerts its therapeutic effect by inhibiting essential bacterial enzymes necessary for genetic replication and cellular survival. Specifically, it targets bacterial DNA gyrase (topoisomerase II) and topoisomerase IV. These crucial enzymes are responsible for uncoiling, repairing, and replicating bacterial DNA during cell division.

By binding to these enzymes, ofloxacin causes double-stranded DNA breakage and disrupts bacterial chromosome structure. This targeted inhibition halts bacterial proliferation and leads to bactericidal cell death, enabling the host immune system to eradicate the remaining bacterial load from infected tissues.

Common Uses

Oflox 400 Mg is indicated for the treatment of documented or strongly suspected bacterial infections caused by susceptible microorganisms. Clinical applications commonly evaluated by healthcare providers include:

• Complicated and uncomplicated urinary tract infections, acute pyelonephritis, and chronic bacterial prostatitis.
• Lower respiratory tract infections, including acute bacterial exacerbations of chronic bronchitis and community-acquired pneumonia.
• Uncomplicated skin and skin structure infections, pelvic inflammatory disease, and certain uncomplicated urethral and cervical gonococcal infections.
• Gastrointestinal infections, such as bacterial diarrhoea or enteric fever, when indicated by antimicrobial susceptibility testing.

Available Strengths

This family is available in 200 mg, 400 mg.

Key Features

• Contains 400 mg of ofloxacin per film-coated tablet.
• Belongs to the synthetic fluoroquinolone class of antimicrobials.
• Dual enzymatic inhibition targeting bacterial DNA gyrase and topoisomerase IV.
• Broad-spectrum bactericidal activity against aerobic Gram-negative and select Gram-positive bacteria.
• Formulated as an oral tablet for systemic systemic distribution.

Benefits

• Provides reliable systemic bactericidal activity against diverse bacterial pathogens.
• Exhibits high oral bioavailability with rapid absorption and wide tissue penetration.
• Directly destroys pathogenic bacterial cells to help resolve acute microbial infections.
• Delivers targeted enzymatic inhibition specific to bacterial replication processes.

Possible Side Effects

• Gastrointestinal disturbances, including nausea, mild diarrhoea, abdominal discomfort, and vomiting.
• Central nervous system effects such as headache, dizziness, lightheadedness, and insomnia.
• Dermatological reactions, including mild skin rashes or localized itching.
• Increased skin sensitivity to light and sunlight (photosensitivity).
• Persistent diarrhoea requiring clinical evaluation for Clostridioides difficile-associated colitis.
• Serious adverse events, including tendinitis, tendon rupture, peripheral neuropathy, and central nervous system toxicity.

Precautions

• Fluoroquinolones carry warnings regarding severe, potentially irreversible disabling side effects involving tendons, muscles, joints, and the nervous system.
• Discontinue immediately if signs of an allergic reaction, such as urticaria, facial swelling, or dyspnoea, occur.
• The risk of tendon inflammation or rupture is elevated in elderly patients, organ transplant recipients, and those taking systemic corticosteroids.
• Use with caution in patients with pre-existing myasthenia gravis, QT interval prolongation, or central nervous system disorders such as epilepsy.

Additional Precautions

• Contraindicated or not recommended during pregnancy and lactation; ask a healthcare professional for product-specific guidance.
• Avoided in children and growing adolescents under 18 years due to potential risks of arthropathy and cartilage damage.
• Dosage adjustments are necessary in patients with renal impairment to prevent accumulation and drug toxicity.
• Avoid exposure to direct sunlight or artificial ultraviolet light during treatment to minimize photosensitivity reactions.

Storage Instructions

• Store below 30°C in a cool, dry place protected from excess heat and direct light.
• Keep tablets inside their original blister packaging until ready for use to protect from moisture.
• Store safely out of reach and sight of children and domestic pets.
• Do not use past the expiration date stated on the packaging.

How to Take

• Take this medication exactly as directed by your prescribing medical practitioner.
• Swallow tablets whole with a full glass of water; do not crush, chew, or split the tablet.
• May be taken with or without food, though consistent daily timing helps maintain steady blood concentrations.
• Complete the full course prescribed by your doctor even if symptoms resolve earlier, in order to prevent treatment failure and antibiotic resistance.
• Ask a healthcare professional for product-specific guidance regarding dosing schedules and duration of therapy.

Drug Interactions

• Antacids containing aluminium or magnesium, iron supplements, sucralfate, and zinc products significantly impair oral absorption.
• Concomitant administration with nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the risk of central nervous system stimulation and seizures.
• Co-administration with warfarin or other oral anticoagulants may enhance anticoagulant efficacy, requiring monitoring of prothrombin time/INR.
• Concurrent use with antidiabetic agents or insulin may cause fluctuations in blood glucose levels.
• Caution is warranted when co-prescribed with Class IA or Class III antiarrhythmics or other QT-prolonging medications.

Why Choose This Product?

• Provides a standardized 400 mg formulation of active ofloxacin.
• Supported by established pharmacopeial quality and manufacturing standards.
• Offers broad-spectrum application across respiratory, urinary, and soft tissue infections as directed by a healthcare professional.
• Delivers consistent oral bioavailability for reliable systemic clinical response.

Frequently Asked Questions (FAQs)

What is Oflox 400 Mg used for?

Oflox 400 Mg is an oral antibiotic used to treat susceptible bacterial infections involving the urinary tract, lower respiratory tract, skin and soft tissues, and reproductive system.

How does ofloxacin clear a bacterial infection?

Ofloxacin inhibits the bacterial enzymes DNA gyrase and topoisomerase IV, stopping bacterial DNA replication and repair, which leads directly to bacterial cell death.

Can I take Oflox 400 Mg with antacids or iron supplements?

No, antacids containing aluminium or magnesium, as well as iron supplements, bind to ofloxacin and prevent proper absorption. They should be separated by at least two hours.

Is Oflox 400 Mg effective against viral infections?

No, Oflox 400 Mg is an antibacterial agent specifically designed for bacterial pathogens; it is completely ineffective against viral infections such as colds or the flu.

What should I do if I experience joint or tendon pain?

If you experience tendon pain, swelling, or inflammation, stop taking the medication immediately, rest the affected limb, and contact your doctor, as fluoroquinolones carry a risk of tendinitis and tendon rupture.

Can Oflox 400 Mg be taken during pregnancy?

Oflox 400 Mg is generally not recommended during pregnancy or breastfeeding due to potential safety risks to cartilage development. Ask a healthcare professional for product-specific guidance.

Should Oflox 400 Mg be taken with food?

It can be taken either with or without food. However, taking it with a glass of water at the same scheduled times each day maintains optimal blood levels.

Why is it important to complete the full antibiotic course?

Completing the entire prescribed course ensures all target bacteria are eliminated, preventing infection recurrence and reducing the development of antibiotic-resistant strains.

Related Products

• Oflox 200 Mg (Ofloxacin)
• Oflox 400 Mg (Ofloxacin)
• Metronidazole 200 Mg Australia
• Amoxicillin 500Mg Capsule Australia
• Levofloxacin 750 Mg Australia